High dose thiamine improves fatigue in multiple sclerosis
The majority of the patients with multiple sclerosis (MS) experience  fatigue. Some observations indicate that fatigue and related manifestations concomitant with MS could be associated with an intracellular mild thiamine deficiency. Although blood thiamine and thiamine pyrophosphate levels were within normal limit in all the patients, high-dose thiamine therapy administered orally or parenterally led to an appreciable improvement of the fatigue.The administration of large quantities of thiamine was effective in reversing the fatigue in MS, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations.


The Physiological Changes of MSMultiple sclerosis attacks the body’s central nervous system and can cause quite severe reactions and symptoms if not properly treated. Here are a few physiological changes of multiple sclerosis (MS) and the effect that they have on your body. Some of the most well-known symptoms of MS can include muscle weakness, vision trouble, coordination problems, memory issues and sensations of numbness. However, you might not realize just how this condition affects the body. It affects the brain and nervous system and each patient’s symptoms can be less or more severe than the next, depending on their individual condition.

A new study appearing in the latest issue of STEM CELLS Translational Medicine is the first to demonstrate that, in fact, adipose-derived stem cells donated by older people are less effective than cells from their younger counterparts.

Biogen Idec, Elan facing suits over Tysabri side effects-Allegedly failed to warn of risks
On Aug. 28 of last year Kimberley Yout, 45, was diagnosed with a rare brain infection that developed as a side effect of Tysabri, a drug she took for six years to keep her MS in check. Yout’s speech became slurred, her gait unsteady, and her future uncertain. Now, she is suing the two companies that marketed Tysabri — Biogen Idec Inc. of Weston and the Irish drug maker Elan Pharmaceuticals Inc.
The lawsuit is one of at least a half-dozen pending in Massachusetts and federal courts in three other states. In each case, plaintiffs are seeking more than $1 million in punitive damages from Biogen Idec and Elan on behalf of patients or their families. After taking Tysabri, the patients developed progressive multifocal leukoencephalopathy, known as PML, an infection of the brain’s white matter that can cause death or severe disability. Her complaint, filed Friday, alleges they failed to adequately warn patients of the risks some face from prolonged use of Tysabri.more

Read more »

Labels: Lemtrada, SUNDAY RECAP, TECFIDERA, Tysabri

 Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis


Symptom overlap in anxiety and multiple sclerosis

Cerebral white matter blood flow and energy metabolism in multiple sclerosis

Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance

Retinal nerve fiber layer thickness in benign multiple sclerosis

International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system

Pediatric onset multiple sclerosis: McDonald criteria 2010 and the contribution of spinal cord MRI

Application of the McDonald 2010 criteria for the diagnosis of multiple sclerosis in an Argentinean cohort of patients with clinically isolated syndromes

Childhood body mass index and multiple sclerosis risk: a long-term cohort study
 
High risk of cardiovascular diseases after diagnosis of multiple sclerosis


Brain Changes May Explain Stroke Risk In Migraine Sufferers

Some people who get migraines do have a slightly higher risk of stroke. And some of the brain changes identified in the study look like mini strokes. "On the MRI migraines look like very tiny strokes," Lipton tells Shots. But the people aren't having any stroke symptoms. Still, Lipton is convinced that the process is the same. "We now know it's a risk factor for these very small silent strokes,"


Migraine and structural changes in the brain: A systematic review and meta-analysis

Migraine prevalence, socioeconomic status, and social causation

Sunbathing more effective than vitamin D in preventing multiple sclerosis
A little ray of sunshine can help combat fatigue and depression and decrease the risk of multiple sclerosis, according to new findings. GETTING a regular dose of sunshine is much more effective than vitamin D at combating fatigue and depression. STUDY: Participants also reported on the length of time they spent sunbathing. It emerged that those who spent longer in the sun suffered less from fatigue and depression.

MS study targets damage affecting nerves
Dr Veronique Miron, MRC for Regenerative Medicine at the University of Edinburgh, explains that "In multiple sclerosis patients, the protective layer surrounding ..

CLICK ON "READ MORE" BELOW FOR 96 MORE STUDIES & ARTICLES
Read more »

Labels: Aubagio, Gilenya, SUNDAY RECAP, TECFIDERA, Tysabri